Granted applications

Artificial Intelligence in Oncology - Supporting scientific research

Gall bladder carcinoma, time for improvement; a bench to bedside research project

(Project manager Doctor P. de Reuver, surgery department, Radboud UMC, initiated 3rd quarter 2017)

Aim of research

The aim of this research is improving the treatment of patients with gall bladder carcinoma through:

  1. Epidemiological research; identification of clinical and pathological risk factors for the development of gall bladder carcinoma.
  2. Fundamental research; identification of genetic risk factors and biomarkers for a quicker diagnosis and treatment with targeted therapies.
  3. Clinical research; optimization of determining the stage of the disease and surgical and systemic therapy of patients with gall bladder carcinoma.

Brief summary of progress / results as of autumn 2020

"Cancer of the gallbladder (so-called gallbladder carcinoma) is a very rare form of cancer. In the Netherlands there are less than 200 new patients with gallbladder cancer per year. Little is known about how gallbladder tumors develop. That is why we have started collecting data in patients with a gallbladder polyp (Polyp trial), gallbladder cancer (Tulyp trial) and we look back at all patients with gallbladder cancer who have been treated in the Netherlands in the past 15 years, and recorded in the Dutch cancer registry ( IKNL). By linking data on bacterial infections (RIVM data), we investigated whether, for example, a bacterial infection (Salmonella) gives a higher risk of developing a bile duct tumor. There appears to be an increased risk after an infection, but additional genetic studies are to follow to further investigate the mechanism of gallbladder cancer in these patients. In addition, our research shows that the prognosis of gallbladder cancer has hardly improved in the Netherlands over the past decade. Patients with early gallbladder tumors often do not receive proper surgery or chemotherapy (published in Cancers). We also investigated the benefit of extensive surgery in patients with advanced gallbladder tumors and whether the jaundice symptom is a reason not to have surgery. This research has been published in the 'Annals of Surgical Oncology' and in the scientific journal “HPB”. In the coming year, we will mainly focus on developing a formula that allows us to better predict the prognosis of patients with gallbladder cancer based on the characteristics of the tumor. And finally, we will focus on the identification of biomarkers that enable early recognition of gallbladder cancer."

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